Mouse ErbB4-ELISA

Description: A cloning plasmid for the ERBB4 gene.

Description: Antibody raised against ERBB4

Description: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Description: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Description: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Description: The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full-length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum. Its expression in breast cancer, pediatric brain cancer and other types of carcinomas has been reported in studies which suggest ErbB4 expression is involved in both normal tissue development and carcinogenesis.

Description: The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full-length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum. Its expression in breast cancer, pediatric brain cancer and other types of carcinomas has been reported in studies which suggest ErbB4 expression is involved in both normal tissue development and carcinogenesis.

Description: The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full-length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum. Its expression in breast cancer, pediatric brain cancer and other types of carcinomas has been reported in studies which suggest ErbB4 expression is involved in both normal tissue development and carcinogenesis.

Description: The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full-length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum. Its expression in breast cancer, pediatric brain cancer and other types of carcinomas has been reported in studies which suggest ErbB4 expression is involved in both normal tissue development and carcinogenesis.

Description: The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full-length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum. Its expression in breast cancer, pediatric brain cancer and other types of carcinomas has been reported in studies which suggest ErbB4 expression is involved in both normal tissue development and carcinogenesis.

Description: The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full-length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum. Its expression in breast cancer, pediatric brain cancer and other types of carcinomas has been reported in studies which suggest ErbB4 expression is involved in both normal tissue development and carcinogenesis.

Description: A polyclonal antibody against Phospho-ERBB4 (Tyr1284). Recognizes Phospho-ERBB4 (Tyr1284) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

Description: A polyclonal antibody against ERBB4. Recognizes ERBB4 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

Description: A polyclonal antibody against ERBB4. Recognizes ERBB4 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

Description: A polyclonal antibody against ERBB4. Recognizes ERBB4 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Description: A polyclonal antibody against Phospho-ERBB4 (Y1284). Recognizes Phospho-ERBB4 (Y1284) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is unconjugated.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to ATTO 390.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to ATTO 488.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to ATTO 565.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to ATTO 594.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to ATTO 633.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to ATTO 655.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to ATTO 680.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to ATTO 700.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to Alkaline Phosphatase.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to APC .

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to APC/Cy7.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to Biotin.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to Dylight 350.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to Dylight 405.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to Dylight 488.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to Dylight 594.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to Dylight 633.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to FITC.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to HRP.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to PE/ATTO 594.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to PerCP.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to RPE .

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA42-56). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to Streptavidin.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is unconjugated.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to ATTO 390.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to ATTO 488.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to ATTO 565.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to ATTO 594.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to ATTO 633.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to ATTO 655.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to ATTO 680.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to ATTO 700.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to Alkaline Phosphatase.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to APC .

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to APC/Cy7.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to Biotin.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to Dylight 350.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to Dylight 405.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to Dylight 488.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to Dylight 594.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to Dylight 633.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to FITC.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to HRP.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to PE/ATTO 594.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to PerCP.

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to RPE .

Description: A polyclonal antibody for ErbB4 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide of human ErbB4 (AA1283-1296). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ErbB4 antibody is conjugated to Streptavidin.

Description: A polyclonal antibody against Phospho-ERBB4 (Tyr1284). Recognizes Phospho-ERBB4 (Tyr1284) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

Description: Recombinant Mouse ErbB4 Protein (Met1-Leu652) fused with a His tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 71.5 kDa. (Accession ID: Q99P91)

Description: Recombinant Mouse ErbB4 Protein (Met1-Leu652) fused with a His tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 71.5 kDa. (Accession ID: Q99P91)

Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ERBB4 / HER4 (Internal). This antibody is tested and proven to work in the following applications:

Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ERBB4 / HER4 (Internal). This antibody is tested and proven to work in the following applications:

Description: A Monoclonal antibody against Human ERBB4. The antibodies are raised in Mouse and are from clone 5G6B4. This antibody is applicable in WB and IHC, FC, ICC, E

Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ERBB4 (N-term). This antibody is tested and proven to work in the following applications:

Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ERBB4 (C-term). This antibody is tested and proven to work in the following applications:

Description: Description of target: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.062 ng/mL

Description: Description of target: binds neuregulins; involved in epithelial-mesenchymal interactions during development; may play a role in tooth morphogenesis [RGD, Feb 2006];Species reactivity: Rat;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.294ng/mL

Description: Description of target: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.;Species reactivity: Human;Application: ;Assay info: Quantitative Sandwich ELISA;Sensitivity: < 0.062 ng/mL

Description: Description of target: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis.22 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family."_x005F_x005F_x000D_Plowman G.D., Culouscou J.-M., Whitney G.S., Green J.M., Carlton G.W., Foy L., Neubauer M.G., Shoyab M._x005F_x005F_x000D_Proc. Natl. Acad. Sci. U.S.A. 90:1746-1750(1993) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM JM-A CYT-1), FUNCTION AS CELL SURFACE RECEPTOR, AUTOPHOSPHORYLATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.Ref.2"A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester."_x005F_x005F_x000D_Elenius K., Corfas G., Paul S., Choi C.J., Rio C., Plowman G.D., Klagsbrun M._x005F_x005F_x000D_J. Biol. Chem. 272:26761-26768(1997) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS JM-A CYT-1 AND JM-B CYT-1), TISSUE SPECIFICITY, FUNCTION AS CELL SURFACE RECEPTOR FOR NRG1 AND BTC, SUBCELLULAR LOCATION, AUTOPHOSPHORYLATION, PROTEOLYTIC PROCESSING.Ref.7"HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers."_x005F_x005F_x000D_Cohen B.D., Green J.M., Foy L., Fell H.P._x005F_x005F_x000D_J. Biol. Chem. 271:4813-4818(1996) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION AS NRG1 RECEPTOR IN REGULATION OF CELL PROLIFERATION, CATALYTIC ACTIVITY, ENZYME REGULATION, AUTOPHOSPHORYLATION, PHOSPHORYLATION AT TYR-1056; TYR-1188 AND TYR-1242, INTERACTION WITH EGFR; SHC1 AND PIK3R1.Ref.9"Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation."_x005F_x005F_x000D_Elenius K., Paul S., Allison G., Sun J., Klagsbrun M._x005F_x005F_x000D_EMBO J. 16:1268-1278(1997) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION AS HBEGF RECEPTOR; IN CELL MIGRATION; CELL PROLIFERATION AND IN ACTIVATION OF PIK3R1, INTERACTION WITH HBEGF AND PIK3R1, AUTOPHOSPHORYLATION.Ref.10"Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases."_x005F_x005F_x000D_Carraway K.L. III, Weber J.L., Unger M.J., Ledesma J., Yu N., Gassmann M., Lai C._x005F_x005F_x000D_Nature 387:512-516(1997) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH NRG2, FUNCTION AS NRG2 RECEPTOR, PHOSPHORYLATION.Ref.14"ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases."_x005F_x005F_x000D_Olayioye M.A., Beuvink I., Horsch K., Daly J.M., Hynes N.E._x005F_x005F_x000D_J. Biol. Chem. 274:17209-17218(1999) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH ERBB2, FUNCTION IN ACTIVATION OF STAT5A.Ref.15"Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase."_x005F_x005F_x000D_Elenius K., Choi C.J., Paul S., Santiestevan E., Nishi E., Klagsbrun M._x005F_x005F_x000D_Oncogene 18:2607-2615(1999) [PubMed] [Europe PMC] [Abstract]Cited for: ALTERNATIVE SPLICING, FUNCTION IN PHOSPHORYLATION AND ACTIVATION OF PIK3R1, INTERACTION WITH NRG1 AND PIKR3R1, AUTOPHOSPHORYLATION, TISSUE SPECIFICITY.Ref.16"Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase."_x005F_x005F_x000D_Harari D., Tzahar E., Romano J., Shelly M., Pierce J.H., Andrews G.C., Yarden Y._x005F_x005F_x000D_Oncogene 18:2681-2689(1999) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION AS NRG4 RECEPTOR IN ACTIVATION OF MAPK1/ERK2 AND MAPK3/ERK1 AND IN CELL PROLIFERATION, INTERACTION WITH NRG4, SUBCELLULAR LOCATION.Ref.17"A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis."_x005F_x005F_x000D_Kainulainen V., Sundvall M., Maatta J.A., Santiestevan E., Klagsbrun M., Elenius K._x005F_x005F_x000D_J. Biol. Chem. 275:8641-8649(2000) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION AS NRG1 RECEPTOR IN CELL PROLIFERATION; MIGRATION; SURVIVAL AND IN PHOSPHORYLATION OF SHC1; ACTIVATION OF MAPK1/ERK2 AND MAPK3/ERK1, ALTERNATIVE SPLICING.Ref.19"Ligand discrimination in signaling through an ErbB4 receptor homodimer."_x005F_x005F_x000D_Sweeney C., Lai C., Riese D.J. II, Diamonti A.J., Cantley L.C., Carraway K.L. III_x005F_x005F_x000D_J. Biol. Chem. 275:19803-19807(2000) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN ACTIVATION OF AKT1; MAPK1/ERK2 AND MAPK3/ERK1, INTERACTION WITH PIK3R1; GRB2; SHC1; BTC; NRG1; NRG2 AND NRG3, LIGAND-SPECIFIC AUTOPHOSPHORYLATION.Ref.21"BIBX1382BS, but not AG1478 or PD153035, inhibits the ErbB kinases at different concentrations in intact cells."_x005F_x005F_x000D_Egeblad M., Mortensen O.H., van Kempen L.C., Jaattela M._x005F_x005F_x000D_Biochem. Biophys. Res. Commun. 281:25-31(2001) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION AS NRG1 RECEPTOR AND IN ACTIVATION OF MAP KINASES, AUTOPHOSPHORYLATION, ENZYME REGULATION.Ref.22"Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells."_x005F_x005F_x000D_Sartor C.I., Zhou H., Kozlowska E., Guttridge K., Kawata E., Caskey L., Harrelson J., Hynes N., Ethier S., Calvo B., Earp H.S. III_x005F_x005F_x000D_Mol. Cell. Biol. 21:4265-4275(2001) [PubMed] [Europe PMC] [Abstract]Cited for: MUTAGENESIS OF LYS-751, FUNCTION IN PROMOTING CELL DIFFERENTIATION AND INHIBITING CELL PROLIFERATION.Ref.23"WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus."_x005F_x005F_x000D_Komuro A., Nagai M., Navin N.E., Sudol M._x005F_x005F_x000D_J. Biol. Chem. 278:33334-33341(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, PROTEOLYTIC PROCESSING, SUBCELLULAR LOCATION, INTERACTION WITH YAP1, MUTAGENESIS OF TYR-1301.Ref.25"The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone."_x005F_x005F_x000D_Williams C.C., Allison J.G., Vidal G.A., Burow M.E., Beckman B.S., Marrero L., Jones F.E._x005F_x005F_x000D_J. Cell Biol. 167:469-478(2004) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH STAT5A, SUBCELLULAR LOCATION, FUNCTION IN NUCLEAR LOCALIZATION OF STAT5A; DNA-BINDING, MUTAGENESIS OF 681-LYS--ARG-684.Ref.27"Presenilin-dependent gamma-secretase processing regulates multiple ERBB4/HER4 activities."_x005F_x005F_x000D_Vidal G.A., Naresh A., Marrero L., Jones F.E._x005F_x005F_x000D_J. Biol. Chem. 280:19777-19783(2005) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, PROTEOLYTIC PROCESSING, MUTAGENESIS OF VAL-675.Ref.28"The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells."_x005F_x005F_x000D_Naresh A., Long W., Vidal G.A., Wimley W.C., Marrero L., Sartor C.I., Tovey S., Cooke T.G., Bartlett J.M., Jones F.E._x005F_x005F_x000D_Cancer Res. 66:6412-6420(2006) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN PROMOTING APOPTOSIS, SUBCELLULAR LOCATION, INTERACTION WITH BCL2.Ref.30"Proteolytic cleavage and phosphorylation of a tumor-associated ErbB4 isoform promote ligand-independent survival and cancer cell growth."_x005F_x005F_x000D_Maatta J.A., Sundvall M., Junttila T.T., Peri L., Laine V.J., Isola J., Egeblad M., Elenius K._x005F_x005F_x000D_Mol. Biol. Cell 17:67-79(2006) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, PHOSPHORYLATION, SUBCELLULAR LOCATION.Ref.31"The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells."_x005F_x005F_x000D_Muraoka-Cook R.S., Sandahl M., Husted C., Hunter D., Miraglia L., Feng S.M., Elenius K., Earp H.S. III_x005F_x005F_x000D_Mol. Biol. Cell 17:4118-4129(2006) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN DIFFERENTIATION OF MAMMARY EPITHELIUM, PROTEOLYTIC PROCESSING, AUTOPHOSPHORYLATION, SUBCELLULAR LOCATION, INTERACTION WITH STAT5A.Ref.33"HER4 D-box sequences regulate mitotic progression and degradation of the nuclear HER4 cleavage product s80HER4."_x005F_x005F_x000D_Strunk K.E., Husted C., Miraglia L.C., Sandahl M., Rearick W.A., Hunter D.M., Earp H.S. III, Muraoka-Cook R.S._x005F_x005F_x000D_Cancer Res. 67:6582-6590(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION OF ERBB4 INTRACELLULAR DOMAIN, PROTEOLYTIC PROCESSING, SUBCELLULAR LOCATION, UBIQUITINATION OF ERBB4 INTRACELLULAR DOMAIN, MUTAGENESIS OF VAL-675; LYS-751; ARG-992; LEU-995 AND ASP-1000.Ref.35"Differential nuclear localization and kinase activity of alternative ErbB4 intracellular domains."_x005F_x005F_x000D_Sundvall M., Peri L., Maatta J.A., Tvorogov D., Paatero I., Savisalo M., Silvennoinen O., Yarden Y., Elenius K._x005F_x005F_x000D_Oncogene 26:6905-6914(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION OF E4ICD, PHOSPHORYLATION, SUBCELLULAR LOCATION OF E4ICD, MUTAGENESIS OF LYS-751.Ref.38"Somatic mutations of ErbB4: selective loss-of-function phenotype affecting signal transduction pathways in cancer."_x005F_x005F_x000D_Tvorogov D., Sundvall M., Kurppa K., Hollmen M., Repo S., Johnson M.S., Elenius K._x005F_x005F_x000D_J. Biol. Chem. 284:5582-5591(2009) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN ACTIVATION OF SIGNALING PATHWAYS, INTERACTION WITH ERBB2, CATALYTIC ACTIVITY, AUTOPHOSPHORYLATION, PHOSPHORYLATION BY ERBB2, ENZYME REGULATION, MUTAGENESIS OF VAL-721; ALA-773; ARG-782; GLU-810; PRO-854; ASP-861; GLU-872 AND THR-926.Ref.40"Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways."_x005F_x005F_x000D_Gilmore-Hebert M., Ramabhadran R., Stern D.F._x005F_x005F_x000D_Mol. Cancer Res. 8:1388-1398(2010) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH TXNL4A; DDX23; MATR3; RBM15; ILF3; TRIM28; U5S1; U2SURP; ITCH; HNRPU; AP2A1; NULC; LEO1; WWP2; MDM2; HXK1 AND ARS2, FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.062 ng/mL

Description: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Description: Rabbit Monoclonal ErbB4/Her4 Antibody. Validated in WB and tested in Human, Mouse, Rat.

Description: Quantitativesandwich ELISA kit for measuring Mouse Receptor tyrosine-protein kinase erbB-4 (ERBB4) in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Description: Quantitativesandwich ELISA kit for measuring Mouse Receptor tyrosine-protein kinase erbB-4(ERBB4) in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.