Related Categories: Apolipoproteins, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cholesterol and Cholesterol Metabolism,
Quality level: 100
Assay: ≥95% (HPLC)
Solubility: H2O:> 1 mg / mL
Storage temperature. −20 ° C
Packaging: 1 mg in a glass bottle
Biochemical / Physiological Actions
COG 1333 or apoE (133-149) is an apolipoprotein E (APOE) fragment that mimics the functional anti-inflammatory and neuroprotective effects of intact apoE protein. It was suggested that the neuroprotective functions of the mimetic result from binding to low-density lipoprotein receptor (LRP) -related protein or LDL receptors, and such binding results in inhibition of the N-methyl-D-aspartate receptor. (NMDA).